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Smith and colleagues performed a case-control study of venous thrombosis and hormone users in postmenopausal women registered in a large health maintenance organization (the Group Health Cooperative) in the state of Washington.
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Two premenopausal patients with resis tant endometriosis were successfully treated with a combination of the aromatase inhibitor anastrozole, Prometrium, calcitrol, and rofecoxib. Both patients had been diagnosed with endometriosis via laparoscopy, and had undergone GnRH suppression.
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Nearly 70% of patients achieving a CR after primary therapy eventually recurred. Most recurrences occurred more than 6 months from completion of primary chemotherapy, and the use of second line agents at the time of recurrence was effective.
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Results from the estrogen-progestin arm of the Womens Health Initiative confirm (after central adjudication of the diagnoses) an increase in venous thrombosis associated with a standard dose of postmenopausal hormone therapy.
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Youre all on the same team right? At times it doesnt seem so. Sometimes, the way people look at the IRB process and its documentation is that its just one more hurdle they have to jump through in order to conduct their research, says Sarah Frankel, PhD, education specialist at the Human Studies Committee of Washington University School of Medicine in St. Louis.
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The Public Access Defibrillation (PAD) trial experience offers clinical trial administrators a firsthand look at how to conduct extensive public education in the absence of individual informed consent.
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In a popular music video, the star is shot in one scene, then in the next, a small plastic bandage covers the purported wound as he continues singing with an arrogant swagger into the next verse. Guns and images of violence are popular entertainment in this country featured in the plot lines of popular movies, music videos, TV shows, and video games.
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The Office for Human Research Protections (OHRP) has released an updated set of Human Subject Regulations Decision Charts, which can help IRBs determine whether an activity amounts to human subjects research that falls within the realm of the IRBs review process.
